Tilmicosin Oral Solution

Ingredient: Tilmicosin 25%

Mechanism of Action:

Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, suppressing bacterial growth (bacteriostatic effect). It concentrates in lung tissue (the primary site of respiratory infections), enhancing efficacy against pulmonary pathogens.

Key Target Pathogens:

Gram-positive bacteria: Streptococcus spp., Staphylococcus spp., Corynebacterium spp.

Gram-negative bacteria: Pasteurella multocida, Mannheimia haemolytica, Haemophilus parasuis, Bordetella bronchiseptica.

Mycoplasmas: Mycoplasma gallisepticum (poultry), Mycoplasma hyopneumoniae (swine), Mycoplasma bovis (cattle).

Species-Specific Toxicity: 

Highly toxic to horses, donkeys, and mules (even small doses cause fatal cardiac toxicity). Do not use in these species, and prevent cross-contamination of their feed/water.

Indications

Dosage

Withdrawal Periods:

Poultry (broilers/turkeys): 5–10 days (slaughter).

Swine: 14–21 days (slaughter).

Cattle: 21–28 days (slaughter); 3–5 days (milk collection for dairy cows).

Sheep/Goats: 10–14 days (slaughter); 3 days (milk collection).

Storage:

Store at 15–25°C (59–77°F) (room temperature). Avoid extreme heat (e.g., near heaters, direct sunlight) or cold (do not freeze)—freezing causes the solution to separate, and heat accelerates tilmicosin breakdown.

Light Protection: Store in a dark cabinet or storage closet.

Keep Dry: Store away from humid areas (e.g., barn waterers, manure pits). Excess moisture can corrode the container cap, leading to leakage or microbial contamination.

Seal Tightly: After each use, screw the cap on fully to prevent moisture entry and evaporation of the solution. Do not transfer the solution to other containers (risk of light exposure or cross-contamination).