Propofol Injection

Ingredient: Propofol

Appearance: This product is a white milky liquid.

Pharmacological Effects:

Propofol is an intravenous sedative-hypnotic drug used for induction and maintenance of anesthesia. The onset time of induced anesthesia ranges from 75~120 seconds after administration. After induction dose administration, the average maintenance duration of anesthesia in dogs is 6.7 minutes. After maintenance dose administration, the average maintenance duration without pre-anesthetic medication is 3.68 minutes. 

When premedicated with Acepromazine, the average maintenance time is 3.80 minutes; when combined with Acepromazine/Butorphanol, the average maintenance time extends to 5.43 minutes.

Propofol enables rapid recovery from anesthesia. Animals can fully stand up within about 20 minutes, while recovery time may be prolonged in animals given pre-anesthetic sedatives.

Pharmacokinetics:

After intravenous injection in dogs, propofol binds highly to plasma proteins and distributes rapidly in the body. It is highly lipophilic and can cross the blood-brain barrier and placental barrier, and may be excreted via breast milk. It is metabolized into inactive conjugates in the liver and excreted through the kidneys.

Drug Interactions:

No pharmacodynamic incompatibility has been observed clinically when propofol is combined with atropine, xylazine, acepromazine, butorphanol, halothane and isoflurane.

Indications:

For induction of anesthesia in dogs.

Dosage and Administration:

Administer intravenously, calculated based on propofol.

For standalone use: 5.5 mg per kg body weight, injected over 40~60 seconds.

For animals with pre-anesthetic medication, dosage and administration rate refer to the table below, adjusted according to the patient’s condition.

Contraindications:

1.Dogs hypersensitive to propofol or its excipients are prohibited from use.

2.Prohibited for dogs unsuitable for general anesthesia or sedation.

Adverse Reactions:

1.Rapid injection or overdose of propofol may cause cardiopulmonary depression, including hypotension, apnea and decreased blood oxygen saturation.

2.Rare adverse reactions in individual dogs include depression, gastrointestinal reactions, cardiovascular inhibition, epilepsy and other symptoms.

Precautions:

1.During administration, maintain unobstructed respiratory tract and continuous monitoring; artificial ventilation and oxygen supply must be available on standby. During propofol maintenance anesthesia, the dog may develop rapid breathing. Monitor closely; apnea may occur after maintenance dose infusion. When transitioning from induction to maintenance anesthesia, additional low-dose propofol is required; apnea may appear during transition.

Apnea may also occur when supplementing propofol to increase anesthetic depth during inhalation anesthesia maintenance.

2.This product must be administered by a licensed veterinarian.

3.Shake well before use; only use homogeneous, intact solutions.

4.Contains no preservatives; strict aseptic technique is required during handling. Discard immediately if contamination is suspected.

5.For single intravenous injection only. Draw liquid into sterile syringe right after opening. One syringe per patient only. Discard unused liquid within 6 hours. Do not mix with other therapeutic drugs before administration.

6.Pre-anesthetic medication may potentiate propofol’s anesthetic/sedative effects and cause significant changes in systolic, diastolic and mean arterial blood pressure.

7.Safety data for pregnant dogs and breeding bitches is unclear. Like other general anesthetics, it crosses the placenta and may be associated with neonatal depression.

8.Safety evaluation for dogs younger than 10 weeks of age is unavailable.

9.Dosage adjustment required for geriatric or debilitated dogs. Dosing mechanism for dogs with renal and/or hepatic failure is unclear.

When combined with anesthetics, closely monitor heart, respiration, liver/kidney function and hypotensive patients.

10.Cats show good induction and maintenance effects, but recovery time will be longer.

11.This product, like other IV anesthetics, may increase myocardial sensitivity to epinephrine-induced ventricular arrhythmia.

Ventricular arrhythmia was observed in 2 out of 145 cats during propofol induction and maintenance anesthesia.

12.No local tissue reaction after extravascular injection.

13.Not for human use. Keep out of reach of children.

14.Human accidental self-injection may lead to death. Adopt access restriction and drug inquiry procedures suitable for clinical scenarios to mitigate transfer risks.

15.Handle with care to avoid accidental self-injection. Overdose causes cardiopulmonary depression. If respiratory depression occurs, remove residual drug from injection site immediately, implement artificial ventilation and oxygen therapy, and seek emergency medical care.

16.Patients allergic to muscle relaxants may also be hypersensitive to propofol; use with caution to avoid allergic reactions.

17.Avoid inhalation, skin and eye direct contact. In case of contact, flush thoroughly with plenty of water for 15 minutes. Seek medical attention if persistent irritation occurs.

18.Do not freeze this product.

Specification: 5ml: 50mg

Package: 5 vials per box

Storage: Sealed, store at 2~25℃

Shelf Life: 12 months