Nano-VitaminAD3E oral solution

Ingredient:

Vitamin A100’000.00IU/ml;

Vitamin D₃ 20’000.00IU/ml; Vitamin E 20mg/ml

 Indications

The solution targets vitamin A, D₃, and/or

E deficiency-related disorders (common in intensively

 raised, young, or poorly fed animals) and supports

key physiological processes. Specific applicable scenarios include:

Livestock (Pigs, Calves, Sheep, Goats, Cattle)

Vitamin A deficiency:

Ocular disorders:

Xerophthalmia (dry eyes), corneal keratinization, or night blindness (reduced vision in low light), leading to increased eye infections or blindness.

Reproductive issues:

 In sows/cows, poor conception rates, embryonic resorption, stillbirths, or weak offspring; in boars/bulls, reduced sperm quality.

Growth & epithelial damage:

Stunted growth in young animals (piglets, calves), and damaged mucous membranes (respiratory, digestive, urinary tracts), increasing susceptibility to infections (e.g., calf pneumonia, piglet diarrhea).

Vitamin D₃ deficiency:

Rickets:

In young animals (weaned piglets, calves), characterized by soft, deformed bones (bowed legs, swollen joints), difficulty standing, or lameness (due to impaired calcium/phosphorus absorption).

Osteomalacia:

In adult animals (sows, dairy cows), causing brittle bones, reduced milk production, or pelvic deformation (leading to dystocia during calving).

Vitamin E deficiency:

Muscular disorders:

Nutritional muscular dystrophy (weakness, lameness) in growing pigs/calves; white muscle disease (muscle degeneration) in lambs.

Immune dysfunction:

Weakened immunity, increasing vulnerability to bacterial/viral infections (e.g., porcine respiratory disease complex, bovine mastitis).

Poultry (Chickens, Ducks, Turkeys, Geese)

Preventive use:

Supplementary feeding during high-stress periods (weaning, transportation, vaccination) to support immunity and reduce deficiency risks.

Prevention in flocks/herds fed diets low in fat-soluble vitamins (e.g., diets with stale grains, limited green forage, or poor fat content—critical for fat-soluble vitamin absorption).

Nano Vitamin AD₃E oral solution advantage

Dramatically Improved Water Solubility and Uniform Dispersion

Traditional Vitamin AD₃E is oil-based, which floats on water, clumps, or separates—leading to uneven intake (some animals get excess, others get none) when administered via drinking water (the most common route for group supplementation).

The nano-formulation solves this by:

Hydrophilic modification: Nanoparticles of vitamins A, D₃, and E are coated with water-attracting (hydrophilic) carriers, enabling them to dissolve uniformly in drinking water (even in cold or hard water). No more oil slicks or sediment at the bottom of water tanks.

Consistent dosing for flocks/herds:

Every animal—whether a shy chick, small piglet, or adult hen—receives the exact recommended dose of all three vitamins. This eliminates “nutrient gaps” and prevents deficiency in vulnerable individuals (e.g., weak chicks, late-weaned piglets).

Significantly Higher Bioavailability (2–3× vs. Traditional Formulations)

Fat-soluble vitamins (A, D₃, E) rely on dietary fat for absorption and are poorly utilized by animals with:

Immature digestive systems (e.g., neonate piglets, 1–2 week-old chicks, newborn calves—lack sufficient bile salts to emulsify oil).

Low-fat diets (common in intensive broiler or weaned pig feed to reduce diarrhea risk).

Nano-formulation overcomes this by:

Larger surface area:

Nanoparticles have a massive surface area-to-volume ratio, increasing contact with the intestinal mucosa (the site of absorption) by 10–100× compared to traditional oil droplets.

Bypassing fat-dependent absorption:

Nanoparticles are small enough to be directly taken up by intestinal epithelial cells (via endocytosis), without requiring fat emulsification. This makes absorption efficient even in fat-poor diets or young animals.

Reduced liver storage burden:

Unlike traditional formulations (where unabsorbed vitamins are excreted or stored as fat), nano-sized vitamins are quickly absorbed into the bloodstream and delivered to target organs (e.g., eyes for vitamin A, bones for vitamin D₃, muscles for vitamin E)—minimizing waste and maximizing utilization.

Faster Correction of Deficiencies and Stronger Preventive Efficacy

Vitamin A, D₃, and E deficiencies cause distinct, often life-threatening diseases (e.g., xerophthalmia from A deficiency, rickets from D₃ deficiency, white muscle disease from E deficiency).

Nano Vitamin AD3E accelerates intervention by:

Rapidly raising blood vitamin levels:

Due to high absorption, it takes 1–2 days to increase circulating vitamin A/D₃/E concentrations—compared to 3–5 days for traditional formulations. This is critical for treating acute deficiencies (e.g., “crazy chick disease” from E deficiency, which kills chicks within 3 days if untreated).

Preventing subclinical deficiencies:

Even when animals show no obvious symptoms (e.g., slow growth, weak immunity), subclinical deficiencies reduce productivity (e.g., lower egg production, poor feed conversion). The nano-formulation ensures consistent vitamin levels in the body, blocking hidden health risks before they affect performance.

Targeted nutrient delivery:

Nanoparticles can be designed to “target” organs in need (e.g., vitamin D₃ to bones, vitamin A to ocular mucosa), enhancing the correction of organ-specific deficiencies (e.g., soft eggshells from D₃ deficiency, dry eyes from A deficiency).

Enhanced Immune Support for Stress and Disease Resistance

Vitamins A, D₃, and E work synergistically to boost immunity:

Vitamin A maintains the integrity of mucous membranes (respiratory, digestive, urinary tracts)—the first line of defense against pathogens.

Vitamin D₃ regulates immune cell function (e.g., activates macrophages to kill bacteria).

Vitamin E acts as an antioxidant, neutralizing free radicals produced during infection or stress (e.g., vaccination, transportation, heat stress).

Nano-formulation amplifies this synergy by:

Delivering vitamins directly to immune organs:

Nanoparticles are transported to the thymus, spleen, and lymph nodes—ensuring immune cells have sufficient vitamins to function.

Strengthening vaccine efficacy: When used 2–3 days before/after vaccination (e.g., Newcastle disease vaccine for poultry, swine fever vaccine for pigs), it improves antibody production by 20–30%—resulting in longer-lasting immunity.

Reducing infection risk:

Animals supplemented with nano AD₃E have 15–25% lower mortality from bacterial/viral diseases (e.g., E. coli diarrhea in piglets, coccidiosis in chicks) compared to those given traditional AD₃E.

Optimized Reproductive Performance and Growth

For breeding animals and growing livestock/poultry, nano AD₃E directly improves productivity by:

For Breeding Animals (Sows, Cows, Layers, Roosters)

Vitamin A: Enhances ovarian function in sows/hens (improves egg quality, reduces embryonic death) and sperm motility in boars/roosters (increases conception rates by 10–15%).

Vitamin D₃: Prevents dystocia in cows/sows (maintains pelvic bone strength) and improves hatchability (supports embryo bone development).

Vitamin E: Reduces stillbirths and weak offspring (protects fetal muscles and organs from oxidative damage).

Nano advantage:

Breeding animals have 8–12% higher litter size (sows/cows) and 5–8% higher hatchability (layers) vs. traditional AD₃E.

For Growing Animals (Broilers, Weaned Piglets, Calves)

Vitamin A: Supports epithelial growth (reduces gut inflammation, improves nutrient absorption).

Vitamin D₃: Promotes calcium/phosphorus absorption (prevents rickets, ensures strong bones—critical for broiler leg health).

Vitamin E: Protects muscle cells (reduces muscular dystrophy, improves meat quality in broilers/pigs).

Nano advantage:

Growing animals reach market weight 3–5 days earlier (broilers) and have 5–7% better feed conversion ratio (FCR) vs. traditional formulations.

Convenient Administration and Labor Savings

For large-scale farms, efficiency is key—and nano AD₃E simplifies supplementation:

No pre-mixing with oil:

Traditional AD₃E requires mixing with oil first to disperse in feed/water, which is time-consuming. Nano AD₃E can be directly added to drinking water (1–2 mL per 10 L water for poultry, 5–10 mL per 100 L water for pigs) without extra steps.

Stable in water for 24 hours:

Unlike traditional oil-based AD₃E (which oxidizes and loses efficacy after 8 hours in water), nano AD₃E remains stable for 24 hours—no need to replace medicated water multiple times a day.

Suitable for all ages:

From 1-day-old chicks to adult cows, the same formulation works (adjust dosage only)—no need to stock multiple supplements for different age groups.

Safety and Cost-Efficiency (Long-Term)

While nano AD₃E may have a slightly higher upfront cost, it offers better long-term value and safety:

Low toxicity risk:

Nanoparticles are absorbed efficiently and do not accumulate in the liver (a common issue with excess traditional AD₃E, which causes vitamin A/D toxicity). Even at therapeutic doses, there is no risk of liver damage or bone calcification.

Reduced nutrient waste:

High bioavailability means 70–80% of vitamins are absorbed (vs. 30–40% for traditional AD₃E). Less unused vitamin is excreted in manure, reducing environmental pollution (e.g., nutrient runoff) and cutting overall supplement costs.

Compatibility with other products:

It does not interact with common feeds (e.g., starter/grower feeds) or veterinary drugs (e.g., antibiotics for respiratory infections)—allowing flexible integration into farm management.

Dosage and Administration

Species	Age/Stage	Usage Type	Dosage (per animal or per kg body weight)	Administration Method	Course of Treatment
Pigs	Piglets (1–4 wks)	Prevention	0.1–0.2 mL per piglet per day (or 0.01–0.02 mL/kg BW)	Mix into milk replacer/drinking water; ensure uniform intake.	7–10 consecutive days (repeat every 4–6 wks if needed)
	Piglets (1–4 wks)	Treatment	0.2–0.3 mL per piglet per day (or 0.02–0.03 mL/kg BW)	Oral drenching (preferred for sick piglets) or medicated water.	5–7 consecutive days
	Sows (gestation/lactation)	Prevention	0.5–1 mL per sow per day	Mix into drinking water or feed (ensure even mixing with concentrate).	10–14 consecutive days (1× per trimester for gestation sows)
Calves	Neonatal (1–4 wks)	Prevention	0.5–1 mL per calf per day (or 0.05–0.1 mL/kg BW)	Mix into milk or oral drenching (use a dosing syringe to avoid aspiration).	10–14 consecutive days
	Neonatal (1–4 wks)	Treatment	1–1.5 mL per calf per day (or 0.1–0.15 mL/kg BW)	Oral drenching (prioritize for calves with rickets/muscular weakness).	7–10 consecutive days
Chickens	Chicks (1–2 wks)	Prevention	0.05–0.1 mL per 10 chicks per day (dilute 1 mL in 10–20 L drinking water for 100 chicks)	Mix into drinking water; replace with fresh medicated water daily.	5–7 consecutive days
	Chicks (1–2 wks)	Treatment	0.1–0.2 mL per 10 chicks per day (dilute 1 mL in 5–10 L drinking water for 100 chicks)	Concentrated medicated water (ensure all chicks drink); prioritize for chicks with ataxia/eye issues.	5–7 consecutive days
	Layers (peak production)	Prevention	0.1–0.2 mL per 10 hens per day (dilute 1 mL in 8–15 L drinking water for 100 hens)	Mix into drinking water; support eggshell quality and hatchability.	10–14 consecutive days (monthly)
Ducks/Turkeys	Ducklings/poults (1–3 wks)	Prevention	0.1–0.15 mL per 10 birds per day (dilute 1 mL in 6–12 L drinking water for 100 birds)	Mix into drinking water; adjust volume based on daily water intake.	7–10 consecutive days

Storage

Temperature:

Store in a cool, dry place at 5–25°C; avoid high temperatures (e.g., near stoves, direct sunlight) or freezing (freezing may cause oil separation or precipitate formation, reducing absorption).

Light protection:

Store in the original opaque packaging (e.g., brown glass bottle or aluminum foil-lined plastic bottle) to prevent photodegradation:

Vitamin A is highly sensitive to light (breaks down into inactive metabolites).

Vitamin E oxidizes rapidly in light, losing antioxidant activity.

Moisture prevention:

Do not store in humid areas (e.g., barn cellars, near water troughs) to avoid bottle corrosion, solution turbidity, or microbial growth (moisture promotes mold in lipid-based formulations).

Sealing:

After each use, tightly screw the bottle cap to prevent:

Oxygen exposure (oxidizes vitamins A and E, reducing efficacy).

Safety isolation:

Store separately from feed, veterinary drugs (especially antibiotics), or human food to avoid cross-contamination.

Keep out of the reach of children and pets (accidental ingestion by children may cause vitamin A/D toxicity; by pets, gastrointestinal upset).

Expiry date: Do not use beyond the expiration date printed on the label