Enrofloxacin Oral Solution

Ingredient: Enrofloxacin 10% Mechanism of Action: Inhibits bacterial DNA gyrase and topoisomerase IV—enzymes critical for DNA replication, transcription, and repair—leading…

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Ingredient: Enrofloxacin 10%

Mechanism of Action:

Inhibits bacterial DNA gyrase and topoisomerase IV—enzymes critical for DNA replication, transcription, and repair—leading to rapid bacterial death (bactericidal effect).

Key Target Pathogens:

Gram-negative bacteria:

Escherichia coli, Salmonella spp., Pasteurella multocida, Haemophilus spp., Klebsiella spp., Bordetella bronchiseptica.

Gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (some strains), Corynebacterium spp..

Mycoplasmas:

Mycoplasma gallisepticum (poultry), Mycoplasma hyopneumoniae (swine), Mycoplasma haemofelis (cats).

Pharmacokinetic Advantage:

Rapidly absorbed after oral administration, widely distributed to tissues (including lungs, kidneys, and intestinal mucosa), and has a long half-life—allowing for once-daily dosing in most species.

Indications

Animal Category	Species	Primary Indications (Caused by Susceptible Pathogens)
Companion Animals	Dogs, Cats	– Respiratory infections: Bronchitis, pneumonia (e.g., Pasteurella, Bordetella, Staphylococcus).- Urinary tract infections (UTIs): Cystitis, pyelonephritis (e.g., E. coli, Klebsiella).- Skin/soft tissue infections: Pyoderma, abscesses, wound infections (e.g., Staphylococcus, Streptococcus).- Gastrointestinal infections: Diarrhea, enteritis (e.g., Salmonella, E. coli).- Mycoplasmosis: (Cats) Mycoplasma haemofelis (feline infectious anemia).
Food-Producing Animals	Poultry (Broilers, Turkeys, Layers)	– Respiratory diseases: Chronic respiratory disease (CRD, Mycoplasma gallisepticum), infectious coryza (Haemophilus paragallinarum), fowl cholera (Pasteurella multocida).- Gastrointestinal diseases: Salmonellosis (Salmonella spp.), colibacillosis (E. coli).- Systemic infections: Septicemia (bacterial blood poisoning) in young chicks/poults.
Food-Producing Animals	Swine	– Respiratory diseases: Porcine respiratory disease complex (PRDC, Mycoplasma hyopneumoniae, Pasteurella multocida, Haemophilus parasuis).- Gastrointestinal diseases: Post-weaning diarrhea (PWD, E. coli), salmonellosis (Salmonella spp.).- Other infections: Metritis (uterine infection) in sows, mastitis (mammary gland infection).
Food-Producing Animals	Cattle, Goats /Sheep	– Respiratory diseases: Bovine respiratory disease (BRD, Pasteurella multocida, Mannheimia haemolytica), sheep/goat pneumonia (Mycoplasma ovipneumoniae).- Gastrointestinal diseases: Calf scours (E. coli, Salmonella), lamb/kid diarrhea.- Udder infections: Mastitis in dairy cattle/goats (e.g., Staphylococcus aureus).

Dosage

Animal Category	Species	Dosage (Based on 10% Enrofloxacin Solution)	Administration Route	Duration
Companion Animals	Dogs, Cats	5–10 mg enrofloxacin per kg of body weight, per day.Equivalent to: 0.05–0.1 mL of 10% solution per kg body weight (once daily).	Direct oral dosing (syringe, mixed with small amount of food if needed).	5–7 days
Food-Producing Animals	Poultry (Broilers, Turkeys)	10–20 mg enrofloxacin per kg of body weight, per day.For group treatment: Mix 1–2 L of 10% solution per 1000 L of drinking water (ensure all birds have access to medicated water).	Drinking water (replace daily to prevent degradation).	5–7 days
Food-Producing Animals	Swine	5–10 mg enrofloxacin per kg of body weight, per day.For group treatment: Mix 0.5–1 L of 10% solution per 1000 L of drinking water.For individual pigs: 0.05–0.1 mL of 10% solution per kg body weight (once daily).	Drinking water (group) or direct oral dosing (individual).	5–7 days
Food-Producing Animals	Cattle (Calves)	5–10 mg enrofloxacin per kg of body weight, per day.Equivalent to: 0.05–0.1 mL of 10% solution per kg body weight (once daily).	Direct oral dosing (syringe).	5–7 days
Food-Producing Animals	Goats/Sheep	5–7.5 mg enrofloxacin per kg of body weight, per day.Equivalent to: 0.05–0.075 mL of 10% solution per kg body weight (once daily).	Direct oral dosing (syringe).	5–7 days

Withdrawal Periods:

Strictly comply with local regulations to avoid residues in food (meat, eggs, milk). Typical reference periods (confirm with product label/local authorities):

Poultry (broilers/turkeys): 5–10 days (slaughter); Layers: 10–14 days (egg collection).

Swine: 10–14 days (slaughter).

Cattle: 14–21 days (slaughter); 4–5 days (milk collection).

Goats/Sheep: 10–14 days (slaughter); 3–5 days (milk collection).

Storage:

Store at 15–25°C (59–77°F).

Keep the solution away from direct or indirect heat

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Enrofloxacin Oral Solution

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