BKC（Benzalkonium Chloride）Plus Glutaraldehyde

Ingredient: BKC（Benzalkonium Chloride）70%+Glutaraldehyde 8% Overview of the Compound System The combination of 70% Benzalkonium Chloride (BKC) (a cationic surfactant disinfectant)…

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Ingredient: BKC（Benzalkonium Chloride）70%+Glutaraldehyde 8%

Overview of the Compound System

The combination of 70% Benzalkonium Chloride (BKC) (a cationic surfactant disinfectant) and 8% Glutaraldehyde (a dialdehyde biocide) creates a synergistic antimicrobial system. Their mechanisms complement each other:

BKC disrupts microbial cell membranes via electrostatic interaction and hydrophobic insertion, acting rapidly against bacteria, fungi, and enveloped viruses.

Glutaraldehyde cross-links microbial proteins and nucleic acids, achieving long-lasting killing effects—even against bacterial spores and non-enveloped viruses (e.g., parvovirus) that BKC alone struggles to inactivate.

This compound is a concentrated stock solution (total active ingredients: 78%) and must be diluted with purified water or neutral buffers before veterinary use. It is widely used in livestock, poultry, companion animals, and aquaculture due to its broad spectrum, resistance to organic matter, and low corrosion (when diluted).

Veterinary Indications

The compound is primarily used for environmental disinfection (facilities, equipment) and targeted surface disinfection (animal skin/mucosa, eggshells). It is not for systemic administration (injection/oral) or use on deep wounds.

Animal Category	Specific Indications	Rationale for Compound Use
Livestock (cattle, pigs, sheep)	– Disinfection of barn floors, feeding troughs, and milking equipment (pre/post-use).- Teat disinfection for dairy cows (prevent mastitis).- Surgical site preparation (e.g., cesarean sections, hoof trimming).	Combats mixed pathogens (e.g., Staphylococcus aureus, E. coli, mastitis-causing bacteria) and resists organic matter (manure, milk residues).
Poultry (chickens, ducks)	– Hatching egg disinfection (soaking/spraying to reduce Salmonella, Newcastle disease virus).- Disinfection of poultry house air ducts, drinkers, and egg trays.- Control of fungal infections (e.g., Aspergillus in hatcheries).	Glutaraldehyde inactivates stubborn pathogens (e.g., avian influenza virus, fungal spores) that BKC alone cannot eliminate.
Companion Animals (dogs, cats)	– Disinfection of kennels, grooming tools, and surgical instruments (e.g., scalpel blades, forceps).- Topical disinfection of skin folds (Bulldogs, Pugs) and minor wounds (cuts, abrasions).- Ear canal cleaning for otitis externa (mixed bacterial/fungal infections).	Synergistic effect targets mixed infections (e.g., Malassezia fungi + Staphylococcus pseudintermedius in hot spots) and reduces resistance risk.
Aquaculture (fish, shrimp)	– Disinfection of aquaculture tanks, nets, and oxygenation equipment.- Bath treatment for fish bacterial/fungal diseases (fin rot, Saprolegnia).- Egg disinfection (prevent fungal colonization in carp, shrimp).	Resists high organic matter in aquaculture water; glutaraldehyde enhances BKC’s efficacy against aquatic pathogens (e.g., Vibrio parahaemolyticus).
Zoo/Wildlife (exotic species)	– Disinfection of enclosures for reptiles (turtles, snakes) and small mammals (rabbits, ferrets).- Equipment disinfection for primate care (prevent cross-species pathogen transmission).	Broad spectrum addresses diverse pathogens (e.g., reptile-specific Aeromonas, primate herpesviruses) and is safe for sensitive species when diluted.

Dosage & Dilution Guidelines

The compound’s high concentration (70% BKC + 8% glutaraldehyde) requires strict dilution to avoid tissue irritation, corrosion, or toxicity. Dilution ratios depend on the target application and animal species.

Key Principle:

Calculate the dilution factor to achieve the target active ingredient concentration (usually 0.1%–2.0% total active ingredients for most uses).

Example: To prepare 10L of 0.5% working solution (total active ingredients):

Dilution factor = 78% (stock) ÷ 0.5% (target) = 156x → Add 64.1 mL of stock to 9935.9 mL of solvent.

Application Scenario	Target Active Ingredient Concentration	Dilution Ratio (Stock : Solvent)	Application Method
Livestock Barn Disinfection	1.0%–2.0%	1:78 to 1:39	Spray or mop; ensure coverage of 100–200 mL/m². Allow 30–60 minutes of contact time before animal re-entry.
Milking Equipment	0.5%–1.0%	1:156 to 1:78	Soak equipment for 15–20 minutes; rinse with purified water before use to avoid milk residue.
Poultry Egg Disinfection	0.2%–0.5%	1:390 to 1:156	Spray eggs (avoid excess runoff) or soak for 5–8 minutes (room temperature, <25°C). Air-dry before incubation.
Companion Animal Wounds	0.1%–0.2%	1:780 to 1:390	Dab with a cotton swab 1–2x daily; avoid contact with eyes, nose, and genitalia. Do not use on deep puncture wounds.
Aquaculture Tank Disinfection	0.3%–0.8% (empty tanks); 0.01%–0.05% (bath treatment)	1:260 to 1:97.5 (empty); 1:7800 to 1:1560 (bath)	Empty tanks: Spray and air-dry for 2 hours. Bath treatment: Immerse fish for 20–30 minutes; monitor for stress (gasping, erratic swimming).
Surgical Instrument Disinfection	1.5%–2.0%	1:52 to 1:39	Soak instruments for 30–45 minutes; rinse with sterile water before use. Avoid aluminum instruments (causes corrosion).

Storage Requirements

Storage Aspect	Requirements
Container	Store in a chemically resistant, airtight container (HDPE plastic or amber glass). Avoid metal (aluminum, iron) containers—glutaraldehyde reacts with metal to form toxic byproducts.
Temperature	Keep in a cool, dry area at 10°C–30°C (50°F–86°F). Do not expose to temperatures >40°C (104°F) (causes glutaraldehyde polymerization) or <0°C (32°F) (causes BKC precipitation).
Light	Protect from direct sunlight and UV radiation. Glutaraldehyde degrades under light, reducing antimicrobial activity. Use opaque containers or store in a dark cabinet.
Compatibility	Do not store near acids (e.g., citric acid), alkalis (e.g., sodium hydroxide), or anionic surfactants (e.g., soaps). These substances neutralize BKC and break down glutaraldehyde.
Shelf Life	Unopened: 2 years (per manufacturer’s label). Opened: Use within 3 months (absorbs moisture/CO₂, reducing pH and efficacy). Discard if the solution turns yellow/brown or develops a pungent odor.
Safety & Labeling	Keep out of reach of children, animals, and untrained staff. Label clearly with: “Veterinary Use Only,” “Concentrated—Toxic if Undiluted,” expiration date, and emergency contact (veterinarian/toxic control).

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BKC（Benzalkonium Chloride）Plus Glutaraldehyde

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