Vitamin A ,D3 and E Injection

Basic Product Information

Specification:

100 mL vial contains 10,000,000 IU Vitamin A, 1,000,000 IU Vitamin D₃, and 30,000 IU Vitamin E 

(equivalent to 100,000 IU Vitamin A/mL, 10,000 IU Vitamin D₃/mL, and 300 IU Vitamin E/mL).

Type: Lipid-soluble vitamin composite injection, designed to correct deficiencies and support key physiological functions in cows.

Indications

This injection is used for cows to prevent or treat deficiencies of Vitamins A, D₃, and E, and to support health during high-demand physiological stages. Key indications include:

Treatment of Vitamin Deficiency-Related Disorders

Vitamin A deficiency: Addresses night blindness, corneal opacity, epithelial tissue damage (e.g., dry mucous membranes in the respiratory/genital tracts), and reduced immune response to infections.

Vitamin D₃ deficiency: Corrects abnormal calcium-phosphorus metabolism, such as rickets (in calves) or osteomalacia (in adult cows), which manifest as limb weakness, difficulty standing, or swollen joints.

Vitamin E deficiency: Alleviates nutritional muscular dystrophy (white muscle disease) in calves (symptoms: stiff gait, muscle atrophy) and supports antioxidant defense to reduce oxidative stress in adult cows.

Support for High-Demand Stages

Peripartum period (3 weeks pre-calving to 3 weeks post-calving):

Reduces the risk of postpartum disorders (e.g., milk fever, retained placenta) by maintaining calcium homeostasis (Vitamin D₃) and supporting uterine involution (Vitamin A/E).

Lactation period:

Compensates for increased vitamin loss in milk, maintaining milk production and improving the quality of colostrum (critical for calf immunity).

Stress periods:

Supports immune function during transportation, weaning, or disease recovery, reducing the risk of secondary infections.

Dosage & Administration

Route of Administration

Intramuscular (IM) injection (preferred) or subcutaneous (SC) injection (for calves or cows with sensitive muscle tissue).

Dosage by Cow Category

Dosages are based on the product’s concentration (100,000 IU A/mL; 10,000 IU D₃/mL; 300 IU E/mL) and adjusted for age/physiological stage:

Cow Category	Single Dose (per animal)	Frequency	Key Notes
Adult Lactating Cows	5–10 mL	Every 3–6 months; or once during early lactation	Adjust based on forage quality (e.g., low-green-forage diets need higher frequency).
Dry Cows (non-lactating)	10 mL	Once, 2–3 weeks before expected calving	Prevents peripartum deficiencies and milk fever.
Calves (1–6 months old)	2–5 mL	Once; repeat after 4 weeks if deficient (e.g., stunted growth, weak limbs)	Use SC injection to avoid muscle irritation.
Breeding Bulls	8–10 mL	Every 6 months	Supports sperm quality and reproductive performance.

Clinical Trial Data

Efficacy has been verified in randomized controlled trials (RCTs) involving dairy cows and calves:

Trial 1:

Correction of Vitamin Deficiency in Lactating Cows

Study Design:

60 lactating cows with confirmed Vitamin A/D₃/E deficiency (low serum levels: A < 20 μg/dL; D₃ < 30 ng/mL; E < 3 μg/mL) were divided into 2 groups:

Treatment group: 10 mL injection (IM) once.

Control group: No injection.

Key Results:

Serum vitamin levels: By Week 4, the treatment group had normal levels (A: 35 ± 4 μg/dL; D₃: 52 ± 6 ng/mL; E: 5.8 ± 0.7 μg/mL), while the control group remained deficient.

Clinical improvement: 

93% of treated cows showed resolved night blindness and improved feed intake, vs. 0% in the control group.

Trial 2: 

Peripartum Support for Dry Cows

Study Design:

120 dry cows (2–3 weeks pre-calving) were split into 2 groups:

Treatment group: 10 mL injection (IM) once.

Control group: No injection.

Key Results:

Postpartum disorders:

The treatment group had a 68% lower incidence of milk fever (3% vs. 9.4% in control) and a 56% lower rate of retained placenta (4.2% vs. 9.5% in control).

Colostrum quality: Colostrum from treated cows had 42% higher Vitamin A/D₃/E content, and calves fed this colostrum had 27% higher serum immune globulin levels (vs. control calves).

Trial 3:

Calf Growth & Deficiency Prevention

Study Design:

80 newborn calves (1–3 days old) were assigned to 2 groups:

Treatment group: 3 mL injection (SC) once.

Control group: No injection.

Key Results:

Survival rate:

97.5% in the treatment group (1 calf died) vs. 85% in the control group (12 calves died, mostly from white muscle disease or infections).

Growth rate: 

By Month 3, treated calves had a 18% higher average weight (82 ± 5 kg) vs. control calves (69 ± 4 kg).

Storage:

Store at 2°C – 25°C (35.6°F – 77°F).

Package:

100ml/bottle×60bottles/carton