Nicarbazin Premix

Ingredient: Nicarbazin 1. Core Indication: Prevention and Control of Coccidiosis The sole and primary indication of Nicarbazin Premix is the prevention…

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Ingredient: Nicarbazin

1. Core Indication: Prevention and Control of Coccidiosis

The sole and primary indication of Nicarbazin Premix is the prevention and treatment of coccidiosis in susceptible animal species. Coccidiosis is caused by Eimeria parasites, which invade the intestinal mucosa of animals, leading to diarrhea, intestinal damage, reduced feed conversion efficiency, and even mass mortality (especially in young animals).

Nicarbazin works by inhibiting the development of Eimeria in the host’s intestinal tract (specifically targeting the schizont and gametocyte stages of the parasite’s life cycle), thereby preventing the parasite from multiplying and causing tissue damage.

2. Target Animal Species and Specific Eimeria Species

Nicarbazin Premix is most widely used in poultry (the primary hosts of clinically significant coccidiosis) and occasionally in other livestock. Its efficacy varies by animal species and the specific Eimeria strain infecting the host.

(1) Primary Target: Poultry

Poultry Species	Indicated Eimeria Species (Common Pathogens)	Key Notes
Broiler Chickens (meat-type chickens)	– Eimeria tenella (causes cecal coccidiosis, the most lethal form)- Eimeria acervulina (causes intestinal coccidiosis, common in young broilers)- Eimeria maxima (causes jejunal coccidiosis, reduces feed efficiency)- Eimeria necatrix (causes severe intestinal damage)	Most widely used in broiler production; effective for both prevention (prophylaxis) and early treatment of mild-to-moderate infections.
Breeder Chickens (parent stock)	Same as broiler chickens (focus on E. tenella, E. maxima)	Used to prevent coccidiosis during rearing (to maintain reproductive performance); must follow strict withdrawal periods to avoid residue in eggs.
Turkeys	– Eimeria adenoeides (causes intestinal coccidiosis)- Eimeria meleagrimitis (causes duodenal coccidiosis)	Efficacy is well-documented; often used in commercial turkey flocks, especially in the first 8-12 weeks of life (high-risk period).
Ducks	– Eimeria anatis (causes duck coccidiosis)- Eimeria danailovi	Less commonly used than in chickens/turkeys, but effective for controlling duck-specific Eimeria strains (use under veterinary guidance).

(2) Secondary Target: Other Livestock (Limited Use)

Nicarbazin Premix has limited applications in other livestock, as alternative anticoccidials are more commonly preferred. It may be used in:

Geese: To control Eimeria truncata (causes renal coccidiosis in geese) and intestinal Eimeria species.

Pigeons: Occasional use for Eimeria labbeana (pigeon coccidiosis), but only in non-racing pigeon flocks (due to potential impact on performance).

Note: It is not indicated for use in cattle, sheep, pigs, or rabbits—these species are infected with different Eimeria strains, and nicarbazin has poor efficacy or potential toxicity in these animals.

Key Distinction: Prevention vs. Treatment

Nicarbazin Premix is primarily used for prophylaxis (prevention) of coccidiosis, but it can also be used for early treatment of mild infections. The difference lies in timing and dosage:

Prevention: Mixed into feed at a low-to-moderate dose (e.g., 125-250 mg nicarbazin per kg of feed) starting from the first day of life (for broilers) or during high-risk periods (e.g., after stress events like vaccination, transport). This stops Eimeria from establishing an infection.

Treatment: Used at a slightly higher dose (per product label) in flocks with early signs of coccidiosis (e.g., soft feces, mild diarrhea, reduced feed intake). It is ineffective for severe infections (where extensive intestinal damage has already occurred—supportive care like electrolyte supplementation is also needed).

Dosage:

1. Primary Species: Poultry

Animal Species	Purpose	Active Nicarbazin Dosage (per kg feed)	Premix Dosage Example (for 20% Nicarbazin Premix)	Duration of Use
Broiler Chickens	Prevention	125–250 mg/kg	0.625–1.25 g/kg feed (625–1250 g/ton of feed)	Day 1 to 28 of life (or 5–7 days before slaughter, avoiding withdrawal period)
Broiler Chickens	Early Treatment	250–300 mg/kg	1.25–1.5 g/kg feed (1250–1500 g/ton of feed)	5–7 days (stop if clinical signs resolve; extend only if directed by a veterinarian)
Turkeys	Prevention	125–200 mg/kg	0.625–1.0 g/kg feed (625–1000 g/ton of feed)	Day 1 to 12 weeks of life (adjust based on risk of coccidiosis)
Turkey Poults	Early Treatment	200–250 mg/kg	1.0–1.25 g/kg feed (1000–1250 g/ton of feed)	5–7 days (avoid use in turkeys >16 weeks old)
Breeder Chickens	Prevention	125–200 mg/kg	0.625–1.0 g/kg feed (625–1000 g/ton of feed)	Only during rearing phase (stop 4 weeks before start of egg production to avoid egg residues)

2. Secondary Species: Geese and Pigeons

Animal Species	Purpose	Active Nicarbazin Dosage (per kg feed)	Duration of Use	Key Notes
Geese	Prevention	150–200 mg/kg	Day 1 to 8 weeks of life	Targets Eimeria truncata (renal coccidiosis); avoid use in adult geese.
Pigeons	Treatment	200–250 mg/kg	5–7 days	For non-racing pigeons only; may reduce performance in racing birds.

Storage: Keep in a dry and cool place not exceeding 30℃ and avoid light.

Packing: 25kg/bag

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